Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (1): 139-142.doi: 10.3969/j.issn.1673-8225.2011. 01.031

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Differentiation of mesenchymal stem cells into cardiomyocyte-like cells in vitro: Drug, microenvironment and method 

Qin Jia-jia, Xian Shao-xiang, Huang Xi-wen, Sun Jing-he   

  1. First Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou  510405, Guangdong Province, China
  • Received:2010-11-02 Revised:2010-12-03 Online:2011-01-01 Published:2011-01-01
  • About author:Qin Jia-jia☆, Doctor, Associate professor, First Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, Guangdong Province, China Opq0340@sina.com
  • Supported by:

    the National Natural Science Foundation of China in 2008, No. 30873397; the Second-Level Grant for the 46th Batch of Post-doctor, No. 20090460756

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Abstract:

BACKGROUND: Cardiomyocyte cannot regenerate. Damaged cardiomyocytes cannot be repaired and differentiate. Clinical traditional Chinese medicine or western medicine, interventional therapy and surgery therapy cannot substitute necrotic myocardium. How to repair necrotic cardiomyocytes is an important topic in the cardiovascular research. Mesenchymal stem cells (MSCs) induced in vitro can differentiate into cardiomyocyte-like cells, which brings hope for the repair and regeneration of damaged cardiomyocytes.
OBJECTIVE: To analyze the progress of inducing MSCs into cardiomyocyte-like cells in vitro to know where we should go in the future.
METHODS: A computer-based online search of articles on the methods of inducing MSCs into cardiomyocytes in vitro was performed in CNKI and Elsevier-Sdol (2000-01/2010-08) with the key words of “mesenchymal stem cells, cardiomyocyte-like cells, induce, the progress of study”. A total of 185 articles on inducing MSCs into cardiomyocyte-like cells in vitro were collected, including 103 Chinese and 82 English. Outdate, repetitive and similar studies were excluded,and 32 were included.
RESULTS AND CONCLUSION: Numerous studies have verified that MSCs could differentiate into cardiomyocytes in vitro under a certain condition. The induction method mainly contained differentiation inducer method and simulated cardiac microenvironment method. The efficiency of differentiation into cardiomyocytes should be elevated. The optimal induction drug and optimal in vitro microenvironment during the differentiation of MSCs into cardiomyocytes should be explored.

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